Impact of Everolimus and Low-Dose Cyclosporin on Cytomegalovirus Replication and Disease in Pediatric Renal Transplantation.
Identifieur interne : 000A82 ( Main/Exploration ); précédent : 000A81; suivant : 000A83Impact of Everolimus and Low-Dose Cyclosporin on Cytomegalovirus Replication and Disease in Pediatric Renal Transplantation.
Auteurs : B. Höcker [Allemagne] ; S. Zencke [Allemagne] ; L. Pape [Allemagne] ; K. Krupka [Allemagne] ; L. Köster [Allemagne] ; A. Fichtner [Allemagne] ; L. Dello Strologo [Italie] ; I. Guzzo [Italie] ; R. Topaloglu [Turquie] ; B. Kranz [Allemagne] ; J. König [Allemagne] ; M. Bald [Allemagne] ; N J A. Webb [Royaume-Uni] ; A. Noyan [Turquie] ; H. Dursun [Turquie] ; S. Marks [Royaume-Uni] ; Z B Ozcakar [Turquie] ; F. Thiel [Allemagne] ; H. Billing [Allemagne] ; M. Pohl [Allemagne] ; H. Fehrenbach [Allemagne] ; P. Schnitzler [Allemagne] ; T. Bruckner [Allemagne] ; T. Ahlenstiel-Grunow [Allemagne] ; B. Tönshoff [Allemagne]Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2016.
Descripteurs français
- KwdFr :
- Ciclosporine (administration et posologie), Complications postopératoires (MeSH), Cytomegalovirus (effets des médicaments et des substances chimiques), Débit de filtration glomérulaire (MeSH), Défaillance rénale chronique (chirurgie), Défaillance rénale chronique (complications), Enfant (MeSH), Facteurs de risque (MeSH), Femelle (MeSH), Humains (MeSH), Immunosuppresseurs (usage thérapeutique), Immunosuppression thérapeutique (MeSH), Infections à cytomégalovirus (prévention et contrôle), Infections à cytomégalovirus (virologie), Mâle (MeSH), Pronostic (MeSH), Rejet du greffon (prévention et contrôle), Rejet du greffon (virologie), Réplication virale (effets des médicaments et des substances chimiques), Survie du greffon (effets des médicaments et des substances chimiques), Taux de survie (MeSH), Tests de la fonction rénale (MeSH), Transplantation rénale (MeSH), Études de suivi (MeSH), Études rétrospectives (MeSH), Évérolimus (usage thérapeutique).
- MESH :
- administration et posologie : Ciclosporine.
- chirurgie : Défaillance rénale chronique.
- effets des médicaments et des substances chimiques : Cytomegalovirus, Réplication virale, Survie du greffon.
- prévention et contrôle : Infections à cytomégalovirus, Rejet du greffon.
- usage thérapeutique : Immunosuppresseurs, Évérolimus.
- virologie : Infections à cytomégalovirus, Rejet du greffon.
- complications : Complications postopératoires, Débit de filtration glomérulaire, Défaillance rénale chronique, Enfant, Facteurs de risque, Femelle, Humains, Immunosuppression thérapeutique, Mâle, Pronostic, Taux de survie, Tests de la fonction rénale, Transplantation rénale, Études de suivi, Études rétrospectives.
English descriptors
- KwdEn :
- Child (MeSH), Cyclosporine (administration & dosage), Cytomegalovirus (drug effects), Cytomegalovirus Infections (prevention & control), Cytomegalovirus Infections (virology), Everolimus (therapeutic use), Female (MeSH), Follow-Up Studies (MeSH), Glomerular Filtration Rate (MeSH), Graft Rejection (prevention & control), Graft Rejection (virology), Graft Survival (drug effects), Humans (MeSH), Immunosuppression (MeSH), Immunosuppressive Agents (therapeutic use), Kidney Failure, Chronic (complications), Kidney Failure, Chronic (surgery), Kidney Function Tests (MeSH), Kidney Transplantation (MeSH), Male (MeSH), Postoperative Complications (MeSH), Prognosis (MeSH), Retrospective Studies (MeSH), Risk Factors (MeSH), Survival Rate (MeSH), Virus Replication (drug effects).
- MESH :
- chemical , administration & dosage : Cyclosporine.
- complications : Kidney Failure, Chronic.
- drug effects : Cytomegalovirus, Graft Survival, Virus Replication.
- prevention & control : Cytomegalovirus Infections, Graft Rejection.
- surgery : Kidney Failure, Chronic.
- chemical , therapeutic use : Everolimus, Immunosuppressive Agents.
- virology : Cytomegalovirus Infections, Graft Rejection.
- Child, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Immunosuppression, Kidney Function Tests, Kidney Transplantation, Male, Postoperative Complications, Prognosis, Retrospective Studies, Risk Factors, Survival Rate.
Abstract
In order to investigate the hypothesis that the mammalian target of rapamycin inhibitor everolimus (EVR) shows anticytomegalovirus (CMV) activity in pediatric patients, we analyzed the impact of EVR-based immunosuppressive therapy on CMV replication and disease in a large cohort (n = 301) of pediatric kidney allograft recipients. The EVR cohort (n = 59), who also received low-dose cyclosporin, was compared with a control cohort (n = 242), who was administered standard-dose cyclosporin or tacrolimus and an antimetabolite, mostly mycophenolate mofetil (91.7%). Multivariate analysis revealed an 83% lower risk of CMV replication in the EVR cohort than in the control cohort (p = 0.005). In CMV high-risk (donor+/recipient-) patients (n = 88), the EVR-based regimen was associated with a significantly lower rate of CMV disease (0% vs. 14.3%, p = 0.046) than the standard regimen. In patients who had received chemoprophylaxis with (val-)ganciclovir (n = 63), the CMV-free survival rates at 1 year and 3 years posttransplant (100%) were significantly (p = 0.015) higher in the EVR cohort (n = 15) than in the control cohort (n = 48; 1 year, 75.0%; 3 years, 63.3%). Our data suggest that in pediatric patients at high risk of CMV, an EVR-based immunosuppressive regimen is associated with a lower risk of CMV disease than a standard-dose calcineurin inhibitor-based regimen.
DOI: 10.1111/ajt.13649
PubMed: 26613840
Affiliations:
- Allemagne, Italie, Royaume-Uni, Turquie
- Angleterre, Bade-Wurtemberg, District de Fribourg-en-Brisgau, District de Karlsruhe, District de Münster, District de Stuttgart, District de Tübingen, Grand Londres, Grand Manchester, Hambourg, Latium, Rhénanie-du-Nord-Westphalie
- Fribourg-en-Brisgau, Hambourg, Heidelberg, Londres, Manchester, Münster, Rome, Stuttgart, Tübingen
Links toward previous steps (curation, corpus...)
Le document en format XML
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Dello Strologo</name><affiliation wicri:level="3"><nlm:affiliation>IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Ospedale Pediatrico Bambino Gesù, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Guzzo, I" sort="Guzzo, I" uniqKey="Guzzo I" first="I" last="Guzzo">I. Guzzo</name><affiliation wicri:level="3"><nlm:affiliation>IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Ospedale Pediatrico Bambino Gesù, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Topaloglu, R" sort="Topaloglu, R" uniqKey="Topaloglu R" first="R" last="Topaloglu">R. Topaloglu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Kranz, B" sort="Kranz, B" uniqKey="Kranz B" first="B" last="Kranz">B. Kranz</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Pediatrics, Pediatric Nephrology, University Children's Hospital, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Pediatrics, Pediatric Nephrology, University Children's Hospital, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Konig, J" sort="Konig, J" uniqKey="Konig J" first="J" last="König">J. König</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Pediatrics, Pediatric Nephrology, University Children's Hospital, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Pediatrics, Pediatric Nephrology, University Children's Hospital, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Bald, M" sort="Bald, M" uniqKey="Bald M" first="M" last="Bald">M. Bald</name><affiliation wicri:level="3"><nlm:affiliation>Olga Children's Hospital, Clinic of Stuttgart, Stuttgart, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Olga Children's Hospital, Clinic of Stuttgart, Stuttgart</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation></author><author><name sortKey="Webb, N J A" sort="Webb, N J A" uniqKey="Webb N" first="N J A" last="Webb">N J A. Webb</name><affiliation wicri:level="3"><nlm:affiliation>Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Center, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Center, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Noyan, A" sort="Noyan, A" uniqKey="Noyan A" first="A" last="Noyan">A. Noyan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Nephrology, Adana Teaching and Research Center, Baskent University, Adana, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pediatric Nephrology, Adana Teaching and Research Center, Baskent University, Adana</wicri:regionArea><wicri:noRegion>Adana</wicri:noRegion></affiliation></author><author><name sortKey="Dursun, H" sort="Dursun, H" uniqKey="Dursun H" first="H" last="Dursun">H. Dursun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Nephrology, Adana Teaching and Research Center, Baskent University, Adana, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pediatric Nephrology, Adana Teaching and Research Center, Baskent University, Adana</wicri:regionArea><wicri:noRegion>Adana</wicri:noRegion></affiliation></author><author><name sortKey="Marks, S" sort="Marks, S" uniqKey="Marks S" first="S" last="Marks">S. Marks</name><affiliation wicri:level="3"><nlm:affiliation>Great Ormond Street Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Great Ormond Street Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ozcakar, Z B" sort="Ozcakar, Z B" uniqKey="Ozcakar Z" first="Z B" last="Ozcakar">Z B Ozcakar</name><affiliation wicri:level="1"><nlm:affiliation>Ankara University Faculty of Medicine, Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Ankara University Faculty of Medicine, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Thiel, F" sort="Thiel, F" uniqKey="Thiel F" first="F" last="Thiel">F. Thiel</name><affiliation wicri:level="3"><nlm:affiliation>University Children's Hospital, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Children's Hospital, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Billing, H" sort="Billing, H" uniqKey="Billing H" first="H" last="Billing">H. Billing</name><affiliation wicri:level="3"><nlm:affiliation>University Children's Hospital, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Children's Hospital, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Pohl, M" sort="Pohl, M" uniqKey="Pohl M" first="M" last="Pohl">M. Pohl</name><affiliation wicri:level="3"><nlm:affiliation>University Children's Hospital, Freiburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Children's Hospital, Freiburg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Fehrenbach, H" sort="Fehrenbach, H" uniqKey="Fehrenbach H" first="H" last="Fehrenbach">H. Fehrenbach</name><affiliation wicri:level="1"><nlm:affiliation>Children's Hospital, Memmingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Children's Hospital, Memmingen</wicri:regionArea><wicri:noRegion>Memmingen</wicri:noRegion><wicri:noRegion>Memmingen</wicri:noRegion><wicri:noRegion>Memmingen</wicri:noRegion></affiliation></author><author><name sortKey="Schnitzler, P" sort="Schnitzler, P" uniqKey="Schnitzler P" first="P" last="Schnitzler">P. Schnitzler</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Bruckner, T" sort="Bruckner, T" uniqKey="Bruckner T" first="T" last="Bruckner">T. Bruckner</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Ahlenstiel Grunow, T" sort="Ahlenstiel Grunow, T" uniqKey="Ahlenstiel Grunow T" first="T" last="Ahlenstiel-Grunow">T. Ahlenstiel-Grunow</name><affiliation wicri:level="1"><nlm:affiliation>Hanover Medical School, Hanover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hanover Medical School, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Tonshoff, B" sort="Tonshoff, B" uniqKey="Tonshoff B" first="B" last="Tönshoff">B. Tönshoff</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics I, University Children's Hospital, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26613840</idno><idno type="pmid">26613840</idno><idno type="doi">10.1111/ajt.13649</idno><idno type="wicri:Area/Main/Corpus">000B45</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000B45</idno><idno type="wicri:Area/Main/Curation">000B45</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000B45</idno><idno type="wicri:Area/Main/Exploration">000B45</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of Everolimus and Low-Dose Cyclosporin on Cytomegalovirus Replication and Disease in Pediatric Renal Transplantation.</title><author><name sortKey="Hocker, B" sort="Hocker, B" uniqKey="Hocker B" first="B" last="Höcker">B. Höcker</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics I, University Children's Hospital, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Zencke, S" sort="Zencke, S" uniqKey="Zencke S" first="S" last="Zencke">S. Zencke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics I, University Children's Hospital, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Pape, L" sort="Pape, L" uniqKey="Pape L" first="L" last="Pape">L. Pape</name><affiliation wicri:level="1"><nlm:affiliation>Hanover Medical School, Hanover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hanover Medical School, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Krupka, K" sort="Krupka, K" uniqKey="Krupka K" first="K" last="Krupka">K. Krupka</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics I, University Children's Hospital, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Koster, L" sort="Koster, L" uniqKey="Koster L" first="L" last="Köster">L. Köster</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics I, University Children's Hospital, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Fichtner, A" sort="Fichtner, A" uniqKey="Fichtner A" first="A" last="Fichtner">A. Fichtner</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics I, University Children's Hospital, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Dello Strologo, L" sort="Dello Strologo, L" uniqKey="Dello Strologo L" first="L" last="Dello Strologo">L. Dello Strologo</name><affiliation wicri:level="3"><nlm:affiliation>IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Ospedale Pediatrico Bambino Gesù, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Guzzo, I" sort="Guzzo, I" uniqKey="Guzzo I" first="I" last="Guzzo">I. Guzzo</name><affiliation wicri:level="3"><nlm:affiliation>IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Ospedale Pediatrico Bambino Gesù, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Topaloglu, R" sort="Topaloglu, R" uniqKey="Topaloglu R" first="R" last="Topaloglu">R. Topaloglu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Kranz, B" sort="Kranz, B" uniqKey="Kranz B" first="B" last="Kranz">B. Kranz</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Pediatrics, Pediatric Nephrology, University Children's Hospital, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Pediatrics, Pediatric Nephrology, University Children's Hospital, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Konig, J" sort="Konig, J" uniqKey="Konig J" first="J" last="König">J. König</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Pediatrics, Pediatric Nephrology, University Children's Hospital, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Pediatrics, Pediatric Nephrology, University Children's Hospital, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Bald, M" sort="Bald, M" uniqKey="Bald M" first="M" last="Bald">M. Bald</name><affiliation wicri:level="3"><nlm:affiliation>Olga Children's Hospital, Clinic of Stuttgart, Stuttgart, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Olga Children's Hospital, Clinic of Stuttgart, Stuttgart</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation></author><author><name sortKey="Webb, N J A" sort="Webb, N J A" uniqKey="Webb N" first="N J A" last="Webb">N J A. Webb</name><affiliation wicri:level="3"><nlm:affiliation>Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Center, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Center, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Noyan, A" sort="Noyan, A" uniqKey="Noyan A" first="A" last="Noyan">A. Noyan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Nephrology, Adana Teaching and Research Center, Baskent University, Adana, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pediatric Nephrology, Adana Teaching and Research Center, Baskent University, Adana</wicri:regionArea><wicri:noRegion>Adana</wicri:noRegion></affiliation></author><author><name sortKey="Dursun, H" sort="Dursun, H" uniqKey="Dursun H" first="H" last="Dursun">H. Dursun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Nephrology, Adana Teaching and Research Center, Baskent University, Adana, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pediatric Nephrology, Adana Teaching and Research Center, Baskent University, Adana</wicri:regionArea><wicri:noRegion>Adana</wicri:noRegion></affiliation></author><author><name sortKey="Marks, S" sort="Marks, S" uniqKey="Marks S" first="S" last="Marks">S. Marks</name><affiliation wicri:level="3"><nlm:affiliation>Great Ormond Street Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Great Ormond Street Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ozcakar, Z B" sort="Ozcakar, Z B" uniqKey="Ozcakar Z" first="Z B" last="Ozcakar">Z B Ozcakar</name><affiliation wicri:level="1"><nlm:affiliation>Ankara University Faculty of Medicine, Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Ankara University Faculty of Medicine, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Thiel, F" sort="Thiel, F" uniqKey="Thiel F" first="F" last="Thiel">F. Thiel</name><affiliation wicri:level="3"><nlm:affiliation>University Children's Hospital, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Children's Hospital, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Billing, H" sort="Billing, H" uniqKey="Billing H" first="H" last="Billing">H. Billing</name><affiliation wicri:level="3"><nlm:affiliation>University Children's Hospital, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Children's Hospital, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Pohl, M" sort="Pohl, M" uniqKey="Pohl M" first="M" last="Pohl">M. Pohl</name><affiliation wicri:level="3"><nlm:affiliation>University Children's Hospital, Freiburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Children's Hospital, Freiburg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Fehrenbach, H" sort="Fehrenbach, H" uniqKey="Fehrenbach H" first="H" last="Fehrenbach">H. Fehrenbach</name><affiliation wicri:level="1"><nlm:affiliation>Children's Hospital, Memmingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Children's Hospital, Memmingen</wicri:regionArea><wicri:noRegion>Memmingen</wicri:noRegion><wicri:noRegion>Memmingen</wicri:noRegion><wicri:noRegion>Memmingen</wicri:noRegion></affiliation></author><author><name sortKey="Schnitzler, P" sort="Schnitzler, P" uniqKey="Schnitzler P" first="P" last="Schnitzler">P. Schnitzler</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Bruckner, T" sort="Bruckner, T" uniqKey="Bruckner T" first="T" last="Bruckner">T. Bruckner</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Ahlenstiel Grunow, T" sort="Ahlenstiel Grunow, T" uniqKey="Ahlenstiel Grunow T" first="T" last="Ahlenstiel-Grunow">T. Ahlenstiel-Grunow</name><affiliation wicri:level="1"><nlm:affiliation>Hanover Medical School, Hanover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hanover Medical School, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Tonshoff, B" sort="Tonshoff, B" uniqKey="Tonshoff B" first="B" last="Tönshoff">B. Tönshoff</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics I, University Children's Hospital, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="eISSN">1600-6143</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child (MeSH)</term><term>Cyclosporine (administration & dosage)</term><term>Cytomegalovirus (drug effects)</term><term>Cytomegalovirus Infections (prevention & control)</term><term>Cytomegalovirus Infections (virology)</term><term>Everolimus (therapeutic use)</term><term>Female (MeSH)</term><term>Follow-Up Studies (MeSH)</term><term>Glomerular Filtration Rate (MeSH)</term><term>Graft Rejection (prevention & control)</term><term>Graft Rejection (virology)</term><term>Graft Survival (drug effects)</term><term>Humans (MeSH)</term><term>Immunosuppression (MeSH)</term><term>Immunosuppressive Agents (therapeutic use)</term><term>Kidney Failure, Chronic (complications)</term><term>Kidney Failure, Chronic (surgery)</term><term>Kidney Function Tests (MeSH)</term><term>Kidney Transplantation (MeSH)</term><term>Male (MeSH)</term><term>Postoperative Complications (MeSH)</term><term>Prognosis (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Risk Factors (MeSH)</term><term>Survival Rate (MeSH)</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Ciclosporine (administration et posologie)</term><term>Complications postopératoires (MeSH)</term><term>Cytomegalovirus (effets des médicaments et des substances chimiques)</term><term>Débit de filtration glomérulaire (MeSH)</term><term>Défaillance rénale chronique (chirurgie)</term><term>Défaillance rénale chronique (complications)</term><term>Enfant (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Immunosuppresseurs (usage thérapeutique)</term><term>Immunosuppression thérapeutique (MeSH)</term><term>Infections à cytomégalovirus (prévention et contrôle)</term><term>Infections à cytomégalovirus (virologie)</term><term>Mâle (MeSH)</term><term>Pronostic (MeSH)</term><term>Rejet du greffon (prévention et contrôle)</term><term>Rejet du greffon (virologie)</term><term>Réplication virale (effets des médicaments et des substances chimiques)</term><term>Survie du greffon (effets des médicaments et des substances chimiques)</term><term>Taux de survie (MeSH)</term><term>Tests de la fonction rénale (MeSH)</term><term>Transplantation rénale (MeSH)</term><term>Études de suivi (MeSH)</term><term>Études rétrospectives (MeSH)</term><term>Évérolimus (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cyclosporine</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Ciclosporine</term></keywords><keywords scheme="MESH" qualifier="chirurgie" xml:lang="fr"><term>Défaillance rénale chronique</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Kidney Failure, Chronic</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cytomegalovirus</term><term>Graft Survival</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Cytomegalovirus</term><term>Réplication virale</term><term>Survie du greffon</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cytomegalovirus Infections</term><term>Graft Rejection</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Infections à cytomégalovirus</term><term>Rejet du greffon</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Kidney Failure, Chronic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Everolimus</term><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Immunosuppresseurs</term><term>Évérolimus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à cytomégalovirus</term><term>Rejet du greffon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cytomegalovirus Infections</term><term>Graft Rejection</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Female</term><term>Follow-Up Studies</term><term>Glomerular Filtration Rate</term><term>Humans</term><term>Immunosuppression</term><term>Kidney Function Tests</term><term>Kidney Transplantation</term><term>Male</term><term>Postoperative Complications</term><term>Prognosis</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Survival Rate</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Complications postopératoires</term><term>Débit de filtration glomérulaire</term><term>Défaillance rénale chronique</term><term>Enfant</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Immunosuppression thérapeutique</term><term>Mâle</term><term>Pronostic</term><term>Taux de survie</term><term>Tests de la fonction rénale</term><term>Transplantation rénale</term><term>Études de suivi</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In order to investigate the hypothesis that the mammalian target of rapamycin inhibitor everolimus (EVR) shows anticytomegalovirus (CMV) activity in pediatric patients, we analyzed the impact of EVR-based immunosuppressive therapy on CMV replication and disease in a large cohort (n = 301) of pediatric kidney allograft recipients. The EVR cohort (n = 59), who also received low-dose cyclosporin, was compared with a control cohort (n = 242), who was administered standard-dose cyclosporin or tacrolimus and an antimetabolite, mostly mycophenolate mofetil (91.7%). Multivariate analysis revealed an 83% lower risk of CMV replication in the EVR cohort than in the control cohort (p = 0.005). In CMV high-risk (donor+/recipient-) patients (n = 88), the EVR-based regimen was associated with a significantly lower rate of CMV disease (0% vs. 14.3%, p = 0.046) than the standard regimen. In patients who had received chemoprophylaxis with (val-)ganciclovir (n = 63), the CMV-free survival rates at 1 year and 3 years posttransplant (100%) were significantly (p = 0.015) higher in the EVR cohort (n = 15) than in the control cohort (n = 48; 1 year, 75.0%; 3 years, 63.3%). Our data suggest that in pediatric patients at high risk of CMV, an EVR-based immunosuppressive regimen is associated with a lower risk of CMV disease than a standard-dose calcineurin inhibitor-based regimen.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26613840</PMID><DateCompleted><Year>2016</Year><Month>12</Month><Day>20</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>3</Issue><PubDate><Year>2016</Year><Month>Mar</Month></PubDate></JournalIssue><Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title><ISOAbbreviation>Am J Transplant</ISOAbbreviation></Journal><ArticleTitle>Impact of Everolimus and Low-Dose Cyclosporin on Cytomegalovirus Replication and Disease in Pediatric Renal Transplantation.</ArticleTitle><Pagination><MedlinePgn>921-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.13649</ELocationID><Abstract><AbstractText>In order to investigate the hypothesis that the mammalian target of rapamycin inhibitor everolimus (EVR) shows anticytomegalovirus (CMV) activity in pediatric patients, we analyzed the impact of EVR-based immunosuppressive therapy on CMV replication and disease in a large cohort (n = 301) of pediatric kidney allograft recipients. The EVR cohort (n = 59), who also received low-dose cyclosporin, was compared with a control cohort (n = 242), who was administered standard-dose cyclosporin or tacrolimus and an antimetabolite, mostly mycophenolate mofetil (91.7%). Multivariate analysis revealed an 83% lower risk of CMV replication in the EVR cohort than in the control cohort (p = 0.005). In CMV high-risk (donor+/recipient-) patients (n = 88), the EVR-based regimen was associated with a significantly lower rate of CMV disease (0% vs. 14.3%, p = 0.046) than the standard regimen. In patients who had received chemoprophylaxis with (val-)ganciclovir (n = 63), the CMV-free survival rates at 1 year and 3 years posttransplant (100%) were significantly (p = 0.015) higher in the EVR cohort (n = 15) than in the control cohort (n = 48; 1 year, 75.0%; 3 years, 63.3%). Our data suggest that in pediatric patients at high risk of CMV, an EVR-based immunosuppressive regimen is associated with a lower risk of CMV disease than a standard-dose calcineurin inhibitor-based regimen.</AbstractText><CopyrightInformation>© Copyright 2016 The American Society of Transplantation and the American Society of Transplant Surgeons.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Höcker</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zencke</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pape</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Hanover Medical School, Hanover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krupka</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Köster</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fichtner</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dello Strologo</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guzzo</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Topaloglu</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kranz</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of General Pediatrics, Pediatric Nephrology, University Children's Hospital, Münster, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>König</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of General Pediatrics, Pediatric Nephrology, University Children's Hospital, Münster, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bald</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Olga Children's Hospital, Clinic of Stuttgart, Stuttgart, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Webb</LastName><ForeName>N J A</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Center, Manchester, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Noyan</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pediatric Nephrology, Adana Teaching and Research Center, Baskent University, Adana, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dursun</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pediatric Nephrology, Adana Teaching and Research Center, Baskent University, Adana, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marks</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Great Ormond Street Hospital, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ozcakar</LastName><ForeName>Z B</ForeName><Initials>ZB</Initials><AffiliationInfo><Affiliation>Ankara University Faculty of Medicine, Ankara, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thiel</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>University Children's Hospital, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Billing</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>University Children's Hospital, Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pohl</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University Children's Hospital, Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fehrenbach</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Children's Hospital, Memmingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schnitzler</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bruckner</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahlenstiel-Grunow</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Hanover Medical School, Hanover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tönshoff</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>02</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Transplant</MedlineTA><NlmUniqueID>100968638</NlmUniqueID><ISSNLinking>1600-6135</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>83HN0GTJ6D</RegistryNumber><NameOfSubstance UI="D016572">Cyclosporine</NameOfSubstance></Chemical><Chemical><RegistryNumber>9HW64Q8G6G</RegistryNumber><NameOfSubstance UI="D000068338">Everolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016572" MajorTopicYN="N">Cyclosporine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & 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MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007677" MajorTopicYN="N">Kidney Function Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016030" MajorTopicYN="Y">Kidney Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011183" MajorTopicYN="Y">Postoperative Complications</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>08</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>11</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>11</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>11</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>11</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26613840</ArticleId><ArticleId IdType="doi">10.1111/ajt.13649</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Italie</li><li>Royaume-Uni</li><li>Turquie</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>District de Fribourg-en-Brisgau</li><li>District de Karlsruhe</li><li>District de Münster</li><li>District de Stuttgart</li><li>District de Tübingen</li><li>Grand Londres</li><li>Grand Manchester</li><li>Hambourg</li><li>Latium</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Fribourg-en-Brisgau</li><li>Hambourg</li><li>Heidelberg</li><li>Londres</li><li>Manchester</li><li>Münster</li><li>Rome</li><li>Stuttgart</li><li>Tübingen</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Hocker, B" sort="Hocker, B" uniqKey="Hocker B" first="B" last="Höcker">B. 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Webb</name></region><name sortKey="Marks, S" sort="Marks, S" uniqKey="Marks S" first="S" last="Marks">S. Marks</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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